Oxygen-enriched water·Kawasaki, Japan·Since 2011

Oxygen,
held in water.

Purified water and oxygen. Nothing else. The oxygen is held in a patented form that survives heat, cold, and years on a shelf. Made in Japan since 2011.

Shop WOX Read the science

Total dissolved oxygen: ≥ 200 mg/L¹
Ingredients: Water, oxygen
Substance patent: US 10,913,037 B2
Bottles sold: 7,000,000+²
Best by: 3 years

Road cyclists mid-race, Team WOX rider in the pack

Team WOX · road race, Japan

Most oxygen water loses its oxygen before you open it. WOX doesn't.

Dissolve oxygen into water the ordinary way and it leaves the way it came. Within hours of opening, most of it is gone.

WOX holds oxygen differently. Its oxygen sits inside a lattice of water molecules, a structure called an oxygen clathrate hydrate. The substance was new enough to earn patents in the United States, Japan, and China. It is stable enough to survive boiling.³ After a month in an open flask, WOX still held three to five times the oxygen of ordinary water.⁴

How it works

Heated to 100 °C: Oxygen retained³
Open 31 days: 30 mg/L remaining⁴
Ordinary water: 6–9 mg/L

WOX 16.9 fl oz bottle, clear PET with red label — WOX 16.9 fl oz (500 mL)

Close-up of the WOX cap with the printed best-by date — Best-by date, printed on every cap

What we measured.

Healthy adults · randomized, double-blind, placebo-controlled crossover

Capillary blood-flow velocity rose within 30 seconds of drinking 4.2 fl oz (125 mL) of WOX, compared with placebo. Blood-oxygen saturation did not differ from placebo.

Progress in Medicine, 2020⁵

First page of the 2020 Progress in Medicine paper

82%

56 of 68 healthy adults · open-label · no placebo group

Blood-oxygen saturation rose in 56 of 68 adults one to three minutes after 5 to 7 fl oz (150–200 mL) of WOX; group means rose 0.8 to 2.0 points. Two commercial oxygen waters labelled 120 and 150 ppm produced no change in the same setting.

Progress in Medicine, 2016⁶

Page from the 2016 Progress in Medicine paper with the SpO₂ bar chart before and after drinking WOX

US patents

One for the substance, one for the process that makes it, one for the method that measures it.

United States Patent and Trademark Office

United States patent certificate for the oxygen clathrate hydrate

Small studies, reported in full. Read the designs and their limits before you buy. The science

Peloton of road cyclists during a race in Japan — Road race, Japan. Team WOX has been sponsored by the company since the 2010s.

Where it earns its place.

Track cyclist in team kit opening a bottle of WOX at the velodrome

Training & Recovery

Sipped before, during, and after sessions. No sugar, no fizz.

Around the session

Two people drinking WOX outdoors under a clear sky

Altitude & Outdoors

Light to carry. Indifferent to heat and cold. Studied at 3,776 m.

Light, stable, studied

Twelve bottles of WOX arranged on a black background

Demanding Environments

Three-year shelf life, no refrigeration. For caches, kits, and remote sites.

Built to wait

Used in Japan·Baseball, golf, cycling, sumo

Sumo wrestler in formal kimono holding a bottle of WOX beside the company founder

Professional golfer holding WOX on the course

Professional baseball player holding a bottle of WOX

Professional soccer player holding two bottles of WOX

Powerboat racer holding WOX in front of a championship poster

In Japan, WOX is used by professional athletes in baseball, golf, cycling, and sumo. The company sponsors some of them. Photographs courtesy of the athletes and MediScience Espoir.

WOX bottles: 10.1 fl oz, a clear bottle, and 16.9 fl oz side by side — The family: 10.1 fl oz and 16.9 fl oz, plus the 8-liter format for dispensers.

It tastes like very soft water. Because it is.

pH 6.9. Zero hardness. No carbonation, no flavor, no sweeteners, no calories. Drink it cold, at room temperature, or warm.

How people drink it in Japan

One 16.9 fl oz bottle a day, a few mouthfuls at a time. On waking. Around training. Before bed. Not chugged.

The water

Takaaki Matsumoto speaking at a lectern — Takaaki Matsumoto, MD, PhD, pharmacist. Lecture, Kawasaki.

Developed by a physician who spent his career on vaccines.

Takaaki Matsumoto is a medical doctor and pharmacist. He worked on infectious-disease therapeutics at Kyowa Hakko and on vaccines at Pasteur Mérieux Connaught before founding MediScience Espoir in Kawasaki in 2004. He built the gas-liquid mixing device that makes WOX and launched the water in 2011. A sixteen-member advisory team across medicine, pharmacy, veterinary science, engineering, and sports science reviews the work.

Our origin

Case of 24 WOX bottles beside its shipping carton — Case of 24, as shipped.

For teams, outfitters, clinics, and distributors.

Case quantities, an 8-liter format with a hot-and-cold dispenser, ingredient supply, and US distribution. A published claims policy your legal team can read in five minutes.

Partner with WOX

What WOX is not.

WOX is not medical oxygen. It does not treat, prevent, or cure any condition, and it is not a substitute for supplemental oxygen, descent, or medical care at altitude. It is water that carries oxygen in a stable form. We measured some things about it. We tell you what they were.

Sources

Label value. Total dissolved oxygen by the patented total-DO method, US Patent 10,018,605 B2. Standard DO meters undercount oxygen held in clathrate form.
MediScience Espoir company data, cumulative to March 2026.
US Patent 10,913,037 B2, claim 1 and examples.
Matsumoto T et al. Prog Med 2016;36:127–130, Fig. 1. Open 4 L flask at 4 °C; membrane-electrode measurement. Ordinary water at 20 °C holds 6–9 mg/L.
Matsumoto T, Matsumoto M, Noguchi I, Hagiwara T. Prog Med 2020;40:547–549. Authors are employees of MediScience Espoir or its research nonprofit.
Matsumoto T, Otsuki K, Taniguchi A, Yamazaki T, Oda K, Hagiwara T. Prog Med 2016;36:127–130. Three sessions in Hiroshima and Kyoto; not blinded, participants placed their own oximeter. Authors include employees of MediScience Espoir.

Oxygen,held in water.